Over the course of the two decades it’s been on,Grey’s Anatomyhas lost more than its fair share of key characters, but some departures have stung more than others, for how abruptly they happened or how their consequences changed the medical drama. With only three original characters still consistently part ofGrey’s Anatomy’s central story, more characters left than those who stayed at Grey Sloan Memorial. WithGrey’s Anatomybecoming known for killing off its main characters, some of its most upsetting departures involved key characters brutally dying, or doing so gratuitously, as their exits were already set up.
However, some departures were upsetting even if the characters leaving didn’t end theirGrey’s Anatomystory dead, but their departure greatly changed the medical drama or impacted other characters extremely negatively. This was the case for at least two original interns’ exits.Some characters’ centrality ensured that their departure could have only entailed their death, as it would have been unbelievable that they’d stay away after their role in the medical drama. Other departures proved upsetting because of how incredibly unfair it was for their storylines to end like that, makingGrey’s Anatomy’s most upsetting departures so for different reasons.
8Lexie Grey
Lexie’s Death Is Among The Saddest Ever In Grey’s Anatomy’s Most Traumatic Episode
Lexie Grey’s departure deserves its spot among the most upsetting because of how and when her death happens. InGrey’s Anatomyseason 8, episode 24, dubbed the most traumatic episodein the entire series, Meredith, Derek, Lexie, Mark, Arizona and Cristina go through a plane crash and spend the whole episode lost in the woods, trying to find the others and take care of each other’s wounds. Lexie is the only one to die at the crash site.
Finding herself where the back part of the plane was unlike the other doctors, Lexie succumbed to injuries in her left arm, pelvis and legs.
Lexie’s departure manages to be heartbreaking due to it happening during an episode where everyone is under an incredible amount of stress, and because of how it happens.Lexie being pinned by parts of the plane makes her emotional death hard to watch, made more heartbreaking by Mark’s love confessionand Meredith and Cristina only getting to them after Lexie’s last breath.
7Derek Shepherd
Derek’s Death Was Heartbreaking & Changed Grey’s Anatomy As It Was Known
Derek’s departure is another one that is particularly difficult to deal with, after a season when the possibility of Meredith and Derek breaking up is explored, only to concludeDerek’s story in the sole way to save his marriage to Meredith. Another unexpected death,Derek’s departure allows him to spend his last day alive as a hero, keeping his patients alive until the arrival of the emergency services.
Derek dying in the aftermath of his car accident is exceptionally upsetting because his doctors make one mistake after another in their treatment of him.Derek’s inner monologue highlights their every mistake to the audience, while he can’t speak due to his injuries,so his doctors do not change their treatment. Although Derek’s departure could have only ended in his death, as other avenues would have cheapened his and Meredith’s relationship, their final moments together are nevertheless amongGrey’s Anatomy’s most excruciating.
6Cristina Yang
Cristina’s Departure Meant The End Of 1 Key Grey’s Anatomy Story
One of the few departures not involving the character dying, Cristina’s still proves incredibly upsetting. Between the attack at the mall making everyone worried about Cristina being there and Cristina’s departure coming after an entire season of fighting between her and Meredith,the odd pacing ofGrey’s Anatomyseason 10’s finale perfectly depicts why that goodbye feels more epochal than others.
Although Cristina’s departure coincides with her making her dreams come true, as she leaves Grey Sloan Memorial to be the director of cardiothoracic surgery at the Klausman Institute for Medical Research, her exit leaves a hole in the medical drama.Meredith and Cristina’s friendship has been as central toGrey’s Anatomyas very few others, making Cristina’s departure mean that the medical drama will have to drastically changeas a result of her exit. Cristina still being missed makes that the case, even if Meredith took to heart Cristina’s most important advice.
5George O’Malley
John Doe Being Revealed To Be George Is 1 Of Grey’s Anatomy’s Most Shocking Developments
Easily amongGrey’s Anatomy’s most upsetting exits, George’s departure is already set up when he dies, as he had decided to enlist while his loved ones planned to convince him not to go. The nature of his whereabouts being unknown and the day passing by with George being impossible to find make George’s last episode extremely chaotic,until the final revelation that their patient John Doe was George through his writing “007” on Meredith’s hand shocks Seattle Grace’s doctorsand audiences.
How unfair it also feels, given how George could have just gone overseas as planned, makes it still one of the most upsetting departures inGrey’s Anatomy.
George’s death marks the first big exit of a main character, and its happening at the same time Izzie is also risking her life makes it all the more painful. How unfair it also feels, given how George could have just gone overseas as planned, makes it still one of the most upsetting departures inGrey’s Anatomy, 16 years after it happened.
4Ellis Grey
How Ellis’s Death Was Intertwined With Meredith Almost Dying Makes It Wholly Upsetting
Ellis Grey has never been one ofGrey’s Anatomy’s most loved characters due to her conflictual relationship with Meredith and the vivid feeling thatEllis hated Meredith inGrey’s Anatomy. Even after her death,Ellis’s relationship with her daughter Meredith continues to be explored, making her one of the medical drama’s most important characters. The difficult relationship between Meredith and Ellis makes Ellis’s death exceptionally upsetting.
One of the last things Ellis shares with Meredith while lucid is her disappointment in seeing Meredith is “no more than ordinary” after she raised her to be an extraordinary human being.
Happening inGrey’s Anatomyseason 3, Ellis ends up at Seattle Grace after collapsing at her care home. Her rare moments of lucidity when she is in the hospital lead to one of the worst fights with Meredith during which she calls her ordinary.Meredith almost drowning happening at the same time Ellis is at Seattle Grace nevertheless makes Ellis’s departure upsetting, as the two meet in Meredith’s dreams, with Ellis coming towards Meredith signifying her dying, while simultaneously pushing Meredith to live.
3Denny Duquette
Denny’s Was Grey’s Anatomy’s First Important & Unexpected Death
Denny Duquette’s is one ofGrey’s Anatomy’s first major deaths, with his departure being too unexpected after Izzie even cut his LVAD to make him worse, so that that would make UNOS give the heart to Denny instead of Erika’s patient. While Denny only becomes important in the context of his relationship with Izzie,his departure is wholly upsetting because of his story up until his death.
Denny’s departure is a majorGrey’s Anatomyseason 2 development and impacts season 3 and beyond, making it easy to understand the reason for how upsetting it is.
Indeed, Izzie going to great lengths to secure Denny his transplant hints at their story ending happily, especially after Denny’s surgery goes well and he and Izzie agree she would come by in her dress to say hi before the hospital prom. However,tragedy strikes when nobody is paying attention to Denny anymore, and a stroke effectively kills him. Denny’s departure is a majorGrey’s Anatomyseason 2 development and impacts season 3 and beyond, making it easy to understand the reason for how upsetting it is.
2Andrew DeLuca
The Consequences Of Andrew’s Death Were Felt In Both Grey’s Anatomy & Station 19
Andrew DeLuca’s is another departure marred by how upsetting his final moments are. After exhibiting signs of mania but also successfully diagnosing Richard’s problem, Andrew’sGrey’s Anatomyseason 17 is characterized by his certainty about one of his patients being trafficked.Everyone at Grey Sloan Memorial takes Andrew’s accusations as a sign he wasn’t okay again, but his ending storyline inGrey’s AnatomyandStation 19vindicates him.
Andrew’s departure lets him go out as a hero, risking his life to save multiple girls from a trafficking ring, and his investigation effectively makes it possible for authorities to apprehend everyone involved. Still, how heartbreaking Andrew’s final moments with Carina and everyone at Grey Sloan are makes his departure difficult to watch.How Andrew’s death affects Carina’s own story inStation 19makes everything even sadder, easily making his departure earn a place among the most upsetting.
1Alex Karev
Alex’s Abrupt Departure & How It Left Jo Makes It Unbelievably Upsetting
Another departure not entailing the character’s death, Alex’s earns its place among the most upsetting because of how his departure happens. Indeed,Alex’s last episode doesn’t even feature him onscreen, as the last time he was seen was during Meredith’s medical license hearing inGrey’s Anatomyseason 16, episode 8. His choice to leave Seattle and Jo unexpectedly, without telling Jo and Meredith what had happened face-to-face, easily makes his exit one of the most infuriating.
All the seasons ofGrey’s Anatomyuntil season 21 are available to stream on Hulu.
Alex’s exit inGrey’s Anatomyseason 16involving a reunion with Izzie and their biological kids makes everything more puzzling in light of his finally being happy with Jo. His decision emotionally destroys Jo in the following seasons, easily making Alex’s exit among the most upsetting and his decision one of the least easy to forgive throughoutGrey’s Anatomy.
